|
KMID : 1011320100030020058
|
|
Journal of Pharmacoepidemiology and Risk Management
2010 Volume.3 No. 2 p.58 ~ p.63
|
|
|
Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis
|
|
Sohn Seong-Wook
|
|
|
Abstract
|
|
|
|
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but the most severe forms of drug hypersensitivity reactions. They are considered variants of a single disease on the basis of similar pathology. The pathomechanisms of SJS/TEN are not fully understood. The hallmark of SJS/TEN is epidermal cell apoptosis, which may be mediated through keratinocyte Fas-FasL interaction or through CD8＋ cytotoxic T cell release of perforin, granzyme, or granulysin. Unfortunately, there are currently no efficacious pharmaceutical treatments proven through large clinical trials. Current treatments are corticosteroids, intravenous immunoglobulin (IVIG), cyclosporine, anti-TNF monoclonal antibodies, which showed contradictory results. Prompt withdrawal of the causative drugs is usually recommended, and may decrease mortality. A better understanding of the underlying mechanisms is required to identify appropriate treatments. Clinicians must remain vigilant about drug hypersensitivity to prevent SJS/TEN.
|
|
|
KEYWORD
|
|
|
Stevens-Johnson syndrome, Toxic epidermal necrolysis, Drug hypersensitivity, Cytotoxic T cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|